Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: A proof of principle on type 2 diabetes

Genetic association studies of age-related, chronic human diseases often suffer from a lack of power to detect modest effects. Here we propose an alternative approach of including healthy centenarians as a more homogeneous and extreme control group. As a proof of principle we focused on type 2 diabe...

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Main Authors: Garagnani, Paolo, Giuliani, Cristina, Pirazzini, Chiara, Olivieri, Fabiola, Bacalini, Maria Giulia, Ostan, Rita, Mari, Daniela, Passarino, Giuseppe, Monti, Daniela, Bonfigli, Anna Rita, Boemi, Massimo, Ceriello, Antonio, Genovese, Stefano, Sevini, Federica, Luiselli, Donata, Tieri, Paolo, Capri, Miriam, Salvioli, Stefano, Vijg, Jan, Suh, Yousin, Delledonne, Massimo, Testa, Roberto, Franceschi, Claudio
פורמט: Artigo
שפה:Inglês
יצא לאור: Impact Journals LLC 2013
נושאים:
Research Paper
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701112/
https://ncbi.nlm.nih.gov/pubmed/23804578
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