The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

Brain-derived neurotrophic factor (BDNF) importantly regulates learning and memory and supports the survival of injured neurons. Reduced BDNF levels have been detected in the brains of Alzheimer’s disease (AD) patients but the exact role of BDNF in the pathophysiology of the disorder remains obscure...

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Autori principali: Rantamäki, Tomi, Kemppainen, Susanna, Autio, Henri, Stavén, Saara, Koivisto, Hennariikka, Kojima, Masami, Antila, Hanna, Miettinen, Pasi O., Kärkkäinen, Elisa, Karpova, Nina, Vesa, Liisa, Lindemann, Lothar, Hoener, Marius C., Tanila, Heikki, Castrén, Eero
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700921/
https://ncbi.nlm.nih.gov/pubmed/23844236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068722
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