Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila

BACKGROUND: Two pathways are responsible for the majority of regulated protein catabolism in eukaryotic cells: the ubiquitin-proteasome system (UPS) and lysosomal self-degradation through autophagy. Both processes are necessary for cellular homeostasis by ensuring continuous turnover and quality con...

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Hlavní autoři: Lőw, Péter, Varga, Ágnes, Pircs, Karolina, Nagy, Péter, Szatmári, Zsuzsanna, Sass, Miklós, Juhász, Gábor
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700814/
https://ncbi.nlm.nih.gov/pubmed/23800266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-14-29
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