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Motivated behaviors and levels of 3α,5α-THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the midbrain ventral tegmental area of proestrous rats

INTRODUCTION: Progesterone (P(4)) and its product, 5α-pregnan-3α-ol-20-one (3α,5α-THP), act in the midbrain ventral tegmental area (VTA) to alter motivated behaviors, such as mating, and motor and anxiety behavior. Of interest is whether 3α,5α-THP formation requires the pregnane xenobiotic receptor...

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Autors principals: Frye, C.A., Koonce, C.J., Walf, A.A., Rusconi, Jamie C.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700579/
https://ncbi.nlm.nih.gov/pubmed/23634744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jsm.12173
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