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Glypican-3–mediated inhibition of CD26 by TFPI: a novel mechanism in hematopoietic stem cell homing and maintenance

Directional migration determines hematopoietic stem/progenitor cell (HSPC) homing, which depends upon the interaction between the chemokine CXCL12 and its receptor CXCR4. CD26 is a widely expressed membrane-bound ectopeptidase that cleaves CXCL12 thereby depleting its chemokine activity. We identifi...

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Detalhes bibliográficos
Main Authors: Khurana, Satish, Margamuljana, Lia, Joseph, Chacko, Schouteden, Sarah, Buckley, Shannon M., Verfaillie, Catherine M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700464/
https://ncbi.nlm.nih.gov/pubmed/23327927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-09-456715
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