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LKB1 Controls Human Bronchial Epithelial Morphogenesis through p114RhoGEF-Dependent RhoA Activation

LKB1 is a Ser/Thr kinase that plays an important role in controlling both energy metabolism and cell polarity in metazoan organisms. LKB1 is also a tumor suppressor, and homozygous, inactivating mutations are found in a wide range of human cancers. In lung cancer, inactivating mutations are found in...

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Bibliografski detalji
Glavni autori: Xu, Xiaojian, Jin, Dan, Durgan, Joanne, Hall, Alan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700127/
https://ncbi.nlm.nih.gov/pubmed/23648482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00154-13
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