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αCP Poly(C) Binding Proteins Act as Global Regulators of Alternative Polyadenylation

We have previously demonstrated that the KH-domain protein αCP binds to a 3′ untranslated region (3′UTR) C-rich motif of the nascent human alpha-globin (hα-globin) transcript and enhances the efficiency of 3′ processing. Here we assess the genome-wide impact of αCP RNA-protein (RNP) complexes on 3′...

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Detalhes bibliográficos
Main Authors: Ji, Xinjun, Wan, Ji, Vishnu, Melanie, Xing, Yi, Liebhaber, Stephen A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700109/
https://ncbi.nlm.nih.gov/pubmed/23629627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01380-12
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