Regulatory Nexus of Synthesis and Degradation Deciphers Cellular Nrf2 Expression Levels

Transcription factor Nrf2 (NF-E2-related factor 2) is essential for oxidative and electrophilic stress responses. While it has been well characterized that Nrf2 activity is tightly regulated at the protein level through proteasomal degradation via Keap1 (Kelch-like ECH-associated protein 1)-mediated...

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Autori principali: Suzuki, Takafumi, Shibata, Tatsuhiro, Takaya, Kai, Shiraishi, Kouya, Kohno, Takashi, Kunitoh, Hideo, Tsuta, Koji, Furuta, Koh, Goto, Koichi, Hosoda, Fumie, Sakamoto, Hiromi, Motohashi, Hozumi, Yamamoto, Masayuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700104/
https://ncbi.nlm.nih.gov/pubmed/23572560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00065-13
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