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AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion

Upregulated ERK1/2 activity is often correlated with AKT activation during prostate cancer (PCa) progression, yet their functional relation needs elucidation. Using androgen-deprived LNCaP cells, in which ERK1/2 activation occurs in strong correlation with AKT activation, we found that AKT-mediated...

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Detalhes bibliográficos
Main Authors: Hong, Seung-Keun, Jeong, Joseph H., Chan, Andrew M., Park, Jong-In
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699957/
https://ncbi.nlm.nih.gov/pubmed/23701950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2013.05.008
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