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Knockdown of sodium channel Na(V)1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia

Inflammatory processes in the sensory ganglia contribute to many forms of chronic pain. We previously showed that local inflammation of the lumbar sensory ganglia rapidly leads to prolonged mechanical pain behaviors and high levels of spontaneous bursting activity in myelinated cells. Abnormal spont...

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Hlavní autoři: Xie, Wenrui, Strong, Judith A., Ye, Ling, Mao, Ju-Xian, Zhang, Jun-Ming
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699898/
https://ncbi.nlm.nih.gov/pubmed/23622763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2013.02.027
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