TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

The lysosomal-autophagic pathway is activated by starvation and plays an important role in both cellular clearance and lipid catabolism. However, the transcriptional regulation of this pathway in response to metabolic cues is currently uncharacterized. Here we show that the transcription factor EB (...

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Main Authors: Settembre, Carmine, De Cegli, Rossella, Mansueto, Gelsomina, Saha, Pradip K., Vetrini, Francesco, Visvikis, Orane, Huynh, Tuong, Carissimo, Annamaria, Palmer, Donna, Klisch, Tiemo Jürgen, Wollenberg, Amanda C., Di Bernardo, Diego, Chan, Lawrence, Irazoqui, Javier E., Ballabio, Andrea
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699877/
https://ncbi.nlm.nih.gov/pubmed/23604321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2718
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