Deficiency of Renal Cortical EGF Increases ENaC Activity and Contributes to Salt-Sensitive Hypertension

Various stimuli, including hormones and growth factors, modulate epithelial sodium channels (ENaCs), which fine-tune Na(+) absorption in the kidney. Members of the EGF family are important for maintaining transepithelial Na(+) transport, but whether EGF influences ENaC, perhaps mediating salt-sensit...

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Détails bibliographiques
Auteurs principaux: Pavlov, Tengis S., Levchenko, Vladislav, O’Connor, Paul M., Ilatovskaya, Daria V., Palygin, Oleg, Mori, Takefumi, Mattson, David L., Sorokin, Andrey, Lombard, Julian H., Cowley, Allen W., Staruschenko, Alexander
Format: Artigo
Langue:Inglês
Publié: American Society of Nephrology 2013
Sujets:
Basic Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699826/
https://ncbi.nlm.nih.gov/pubmed/23599382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012080839
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