Protein Kinase R Modulates c-Fos and c-Jun Signaling to Promote Proliferation of Hepatocellular Carcinoma with Hepatitis C Virus Infection

Double-stranded RNA-activated protein kinase R (PKR) is known to be upregulated by hepatitis C virus (HCV) and overexpressed in hepatocellular carcinoma (HCC). However, the precise roles of PKR in HCC with HCV infection remain unclear. Two HCV replicating cell lines (JFH-1 and H77s), generated by tr...

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Detalhes bibliográficos
Main Authors: Watanabe, Takao, Hiasa, Yoichi, Tokumoto, Yoshio, Hirooka, Masashi, Abe, Masanori, Ikeda, Yoshio, Matsuura, Bunzo, Chung, Raymond T., Onji, Morikazu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699507/
https://ncbi.nlm.nih.gov/pubmed/23844083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067750
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