Stimulated hepatic stellate cell promotes progression of hepatocellular carcinoma due to protein kinase R activation

Hepatic stellate cells (HSCs) were reported to promote the progression of hepatocellular carcinoma (HCC), however its mechanism is uncertain. We previously reported that protein kinase R (PKR) in hepatocytes regulated HCC proliferation. In this study, we focused on the role of PKR in HSCs, and clari...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Imai, Yusuke, Yoshida, Osamu, Watanabe, Takao, Yukimoto, Atsushi, Koizumi, Yohei, Ikeda, Yoshio, Tokumoto, Yoshio, Hirooka, Masashi, Abe, Masanori, Hiasa, Yoichi
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386440/
https://ncbi.nlm.nih.gov/pubmed/30794626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0212589
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