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Inhibition of leukemic cells by valproic acid, an HDAC inhibitor, in xenograft tumors
The chimeric fusion protein, AML1-ETO, generated by translocation of t(8;21), abnormally recruits histone deacetylase (HDAC) to the promoters of AML1 target genes, resulting in transcriptional repression of the target genes and development of t(8;21) acute myeloid leukemia. Abnormal expression of cy...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Dove Medical Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3699303/ https://ncbi.nlm.nih.gov/pubmed/23836985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S46135 |
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