SMAD3 Deficiency Promotes Inflammatory Aortic Aneurysms in Angiotensin II–Infused Mice Via Activation of iNOS

BACKGROUND: Ninety percent of the patients carrying distinct SMAD3 mutations develop aortic aneurysms and dissections, called aneurysms‐osteoarthritis syndrome (AOS). However, the etiology and molecular events downstream of SMAD3 leading to the pathogenesis of aortic aneurysms in these patients stil...

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Detalhes bibliográficos
Main Authors: Tan, Chek K., Tan, Eddie H., Luo, Baiwen, Huang, Charlotte L., Loo, Joachim S., Choong, Cleo, Tan, Nguan S.
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698794/
https://ncbi.nlm.nih.gov/pubmed/23782924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000269
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