Deletion of Phd2 in Myeloid Lineage Attenuates Hypertensive Cardiovascular Remodeling

BACKGROUND: Hypertension induces cardiovascular hypertrophy and fibrosis. Infiltrated macrophages are critically involved in this process. We recently reported that inhibition of prolyl hydroxylase domain protein 2 (PHD2), which hydroxylates the proline residues of hypoxia‐inducible factor‐α (HIF‐α)...

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Detalhes bibliográficos
Main Authors: Ikeda, Jiro, Ichiki, Toshihiro, Matsuura, Hirohide, Inoue, Eriko, Kishimoto, Junji, Watanabe, Aya, Sankoda, Chikahiro, Kitamoto, Shiro, Tokunou, Tomotake, Takeda, Kotaro, Fong, Guo‐Hua, Sunagawa, Kenji
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698781/
https://ncbi.nlm.nih.gov/pubmed/23778187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000178
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