Increased Expression of HCN Channels in the Ventricular Myocardium Contributes to Enhanced Arrhythmicity in Mouse Failing Hearts

BACKGROUND: The efficacy of pharmacological interventions to prevent sudden arrhythmic death in patients with chronic heart failure remains limited. Evidence now suggests increased ventricular expression of hyperpolarization‐activated cation (HCN) channels in hypertrophied and failing hearts contrib...

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Detalhes bibliográficos
Main Authors: Kuwabara, Yoshihiro, Kuwahara, Koichiro, Takano, Makoto, Kinoshita, Hideyuki, Arai, Yuji, Yasuno, Shinji, Nakagawa, Yasuaki, Igata, Sachiyo, Usami, Satoru, Minami, Takeya, Yamada, Yuko, Nakao, Kazuhiro, Yamada, Chinatsu, Shibata, Junko, Nishikimi, Toshio, Ueshima, Kenji, Nakao, Kazuwa
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698776/
https://ncbi.nlm.nih.gov/pubmed/23709563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000150
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