Genetic Deletion of Uncoupling Protein 3 Exaggerates Apoptotic Cell Death in the Ischemic Heart Leading to Heart Failure

BACKGROUND: Uncoupling protein 3 (ucp3) is a member of the mitochondrial anion carrier superfamily of proteins uncoupling mitochondrial respiration. In this study, we investigated the effects of ucp3 genetic deletion on mitochondrial function and cell survival under low oxygen conditions in vitro an...

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Bibliografiske detaljer
Main Authors: Perrino, Cinzia, Schiattarella, Gabriele G., Sannino, Anna, Pironti, Gianluigi, Petretta, Maria Piera, Cannavo, Alessandro, Gargiulo, Giuseppe, Ilardi, Federica, Magliulo, Fabio, Franzone, Anna, Carotenuto, Giuseppe, Serino, Federica, Altobelli, Giovanna G., Cimini, Vincenzo, Cuocolo, Alberto, Lombardi, Assunta, Goglia, Fernando, Indolfi, Ciro, Trimarco, Bruno, Esposito, Giovanni
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2013
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698767/
https://ncbi.nlm.nih.gov/pubmed/23688674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000086
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