Cell cycle-arrested tumor cells exhibit increased sensitivity towards TRAIL-induced apoptosis

Resting tumor cells represent a huge challenge during anticancer therapy due to their increased treatment resistance. TNF-related apoptosis-inducing ligand (TRAIL) is a putative future anticancer drug, currently in phases I and II clinical studies. We recently showed that TRAIL is able to target leu...

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Autores principales: Ehrhardt, H, Wachter, F, Grunert, M, Jeremias, I
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698546/
https://ncbi.nlm.nih.gov/pubmed/23744361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.179
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