Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: putative anticancer mechanism of antioxidants

Plant-derived dietary antioxidants have attracted considerable interest in recent past for their chemopreventive and cancer therapeutic abilities in animal models. Thymoquinone (TQ) is the major bioactive constituent of volatile oil of Nigella sativa and has been shown to exert various pharmacologic...

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Autori principali: Zubair, H, Khan, H Y, Sohail, A, Azim, S, Ullah, M F, Ahmad, A, Sarkar, F H, Hadi, S M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698541/
https://ncbi.nlm.nih.gov/pubmed/23744360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.172
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