A Cleavable N-Terminal Signal Peptide Promotes Widespread Olfactory Receptor Surface Expression in HEK293T Cells

Olfactory receptors (ORs) are G protein-coupled receptors that detect odorants in the olfactory epithelium, and comprise the largest gene family in the genome. Identification of OR ligands typically requires OR surface expression in heterologous cells; however, ORs rarely traffic to the cell surface...

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Bibliographic Details
Main Authors: Shepard, Blythe D., Natarajan, Niranjana, Protzko, Ryan J., Acres, Omar W., Pluznick, Jennifer L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698168/
https://ncbi.nlm.nih.gov/pubmed/23840901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068758
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