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β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans

OBJECTIVE: Little is known about the capacity, mechanisms, or timing of growth in β-cell mass in humans. We sought to establish if the predominant expansion of β-cell mass in humans occurs in early childhood and if, as in rodents, this coincides with relatively abundant β-cell replication. We also s...

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Main Authors: Meier, Juris J., Butler, Alexandra E., Saisho, Yoshifumi, Monchamp, Travis, Galasso, Ryan, Bhushan, Anil, Rizza, Robert A., Butler, Peter C.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697779/
https://ncbi.nlm.nih.gov/pubmed/18334605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1369
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