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Genomewide Screen for Modulators of Evolvability under Toxic Antibiotic Exposure
Antibiotic resistance is generally selected within a window of concentrations high enough to inhibit wild-type growth but low enough for new resistant mutants to emerge. We studied de novo evolution of resistance to ciprofloxacin in an Escherichia coli knockout library. Five null mutations had littl...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3697378/ https://ncbi.nlm.nih.gov/pubmed/23669383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02454-12 |
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