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Redefining the Role of the β-Lactamase Locus in Methicillin-Resistant Staphylococcus aureus: β-Lactamase Regulators Disrupt the MecI-Mediated Strong Repression on mecA and Optimize the Phenotypic Expression of Resistance in Strains with Constitutive mecA Expression

In response to β-lactam chemotherapy, Staphylococcus aureus has acquired two resistance determinants: blaZ, coding for β-lactamase, which confers resistance to penicillins only, and mecA, coding for an extra cell wall cross-linking enzyme with reduced affinity for virtually all other β-lactams. The...

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Detaylı Bibliyografya
Asıl Yazarlar: Arêde, Pedro, Ministro, Joana, Oliveira, Duarte C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697340/
https://ncbi.nlm.nih.gov/pubmed/23587945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02621-12
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