Mutations in panD encoding aspartate decarboxylase are associated with pyrazinamide resistance in Mycobacterium tuberculosis

Pyrazinamide (PZA) is a frontline anti-tuberculosis drug that plays a crucial role in the treatment of both drug susceptible and multidrug-resistant tuberculosis (MDR-TB). Resistance to PZA is most commonly associated with mutations in the pncA gene encoding nicotinamidase/pyrazinamidase which conve...

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Bibliografiske detaljer
Main Authors: Zhang, Shuo, Chen, Jiazhen, Shi, Wanliang, Liu, Wei, Zhang, Wenhong, Zhang, Ying
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697303/
https://ncbi.nlm.nih.gov/pubmed/26038471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emi.2013.38
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