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Reversal of Fluconazole Resistance by Sulfated Sterols from the Marine Sponge Topsentia sp.
Bioassay-guided fractionation of the extract of Topsentia sp. led to the identification of two new sulfated sterols, geodisterol-3-O-sulfite (1) and 29-demethylgeodisterol-3-O-sulfite (2), the active constituents reversing efflux pump-mediated fluconazole resistance. Both compounds enhanced the acti...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3697152/ https://ncbi.nlm.nih.gov/pubmed/19653640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np900177m |
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