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Reversal of Fluconazole Resistance by Sulfated Sterols from the Marine Sponge Topsentia sp.

Bioassay-guided fractionation of the extract of Topsentia sp. led to the identification of two new sulfated sterols, geodisterol-3-O-sulfite (1) and 29-demethylgeodisterol-3-O-sulfite (2), the active constituents reversing efflux pump-mediated fluconazole resistance. Both compounds enhanced the acti...

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Detalhes bibliográficos
Main Authors: DiGirolamo, Jessica A., Li, Xing-Cong, Jacob, Melissa R., Clark, Alice M., Ferreira, Daneel
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697152/
https://ncbi.nlm.nih.gov/pubmed/19653640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np900177m
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