Evaluation of an In Silico PBPK Post-Bariatric Surgery Model through Simulating Oral Drug Bioavailability of Atorvastatin and Cyclosporine

An increasing prevalence of morbid obesity has led to dramatic increases in the number of bariatric surgeries performed. Altered gastrointestinal physiology following surgery can be associated with modified oral drug bioavailability (F(oral)). In the absence of clinical data, an indication of change...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Darwich, A S, Pade, D, Rowland-Yeo, K, Jamei, M, Åsberg, A, Christensen, H, Ashcroft, D M, Rostami-Hodjegan, A
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2013
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697036/
https://ncbi.nlm.nih.gov/pubmed/23903405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2013.23
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