Chondroadherin Fragmentation Mediated by the Protease HTRA1 Distinguishes Human Intervertebral Disc Degeneration from Normal Aging

Chondroadherin, a member of the leucine-rich repeat family, has previously been demonstrated to be fragmented in some juveniles with idiopathic scoliosis. This observation led us to investigate adults with disc degeneration. Immunoblotting analysis demonstrated that non-degenerate discs from three d...

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Bibliographische Detailangaben
Hauptverfasser: Akhatib, Bashar, Önnerfjord, Patrik, Gawri, Rahul, Ouellet, Jean, Jarzem, Peter, Heinegård, Dick, Mort, John, Roughley, Peter, Haglund, Lisbet
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696698/
https://ncbi.nlm.nih.gov/pubmed/23673665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.443010
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