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Dominant protein interactions that influence the pathogenesis of conformational diseases

Misfolding of exportable proteins can trigger endocrinopathies. For example, misfolding of insulin can result in autosomal dominant mutant INS gene–induced diabetes of youth, and misfolding of thyroglobulin can result in autosomal recessive congenital hypothyroidism with deficient thyroglobulin. Bot...

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Main Authors: Wright, Jordan, Wang, Xiaofan, Haataja, Leena, Kellogg, Aaron P., Lee, Jaemin, Liu, Ming, Arvan, Peter
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696544/
https://ncbi.nlm.nih.gov/pubmed/23722904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67260
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