Phase 1 study of intravenous rigosertib (ON 01910.Na), a novel benzyl styryl sulfone structure producing G2/M arrest and apoptosis, in adult patients with advanced cancer

Rigosertib (ON 01910.Na), a synthetic novel benzyl styryl sulfone, was administered to 28 patients with advanced cancer in a Phase I trial in order to characterize its pharmacokinetic profile, determine the dose-limiting toxicities (DLT), define the recommended phase II dose (RPTD) and to document a...

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Detalhes bibliográficos
Main Authors: Ohnuma, Takao, Lehrer, Deborah, Ren, Chen, Cho, Sool Yeon, Maniar, Manoj, Silverman, Lewis, Sung, Max, Gretz, Herbert F, Benisovich, Vladimir, Navada, Shyamala, Akahoho, Eugene, Wilck, Eric, Taft, David R, Roboz, John, Wilhelm, Francois, Holland, James F
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696538/
https://ncbi.nlm.nih.gov/pubmed/23841031
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