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Phase I Clinical Trial of Oral Rigosertib in Patients with Myelodysplastic Syndromes
The multi-kinase inhibitor rigosertib (ON 01910.Na) induces mitotic arrest and apoptosis in myeloblasts, while sparing normal cells. The purpose of this study was to determine the pharmacokinetic profile, maximum-tolerated dose (MTD), safety, and clinical activity of an oral formulation of rigoserti...
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| Publicado no: | Br J Haematol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4685467/ https://ncbi.nlm.nih.gov/pubmed/23789936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.12436 |
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