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Nitric oxide may inhibit neointimal hyperplasia by decreasing isopeptidase T levels and activity in the vasculature

OBJECTIVE: Isopeptidase T is a cysteine protease deubiquitinating enzyme that hydrolyzes unanchored polyubiquitin chains to free monoubiquitin. Nitric oxide (NO) decreases 26S proteasome activity in vascular smooth muscle cells (VSMCs) and inhibits neointimal hyperplasia in animal models. As NO can...

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Bibliografiske detaljer
Main Authors: Tsihlis, Nick D., Kapadia, Muneera R., Vavra, Ashley K., Flannery, Walker D., Oustwani, Christopher S., Jiang, Qun, Kibbe, Melina R.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696405/
https://ncbi.nlm.nih.gov/pubmed/23375434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jvs.2012.10.066
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