Nitric oxide may inhibit neointimal hyperplasia by decreasing isopeptidase T levels and activity in the vasculature

OBJECTIVE: Isopeptidase T is a cysteine protease deubiquitinating enzyme that hydrolyzes unanchored polyubiquitin chains to free monoubiquitin. Nitric oxide (NO) decreases 26S proteasome activity in vascular smooth muscle cells (VSMCs) and inhibits neointimal hyperplasia in animal models. As NO can...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tsihlis, Nick D., Kapadia, Muneera R., Vavra, Ashley K., Flannery, Walker D., Oustwani, Christopher S., Jiang, Qun, Kibbe, Melina R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696405/
https://ncbi.nlm.nih.gov/pubmed/23375434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jvs.2012.10.066
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