Smooth muscle relaxation and activation of the large conductance Ca(++) – activated K(+) (BK(Ca)) channel by novel oestrogens

BACKGROUND AND PURPOSE: Oestrogens can interact directly with membrane receptors and channels and can activate vascular BK(Ca) channels. We hypothesized that novel oestrogen derivatives could relax smooth muscle by an extracllular effect on the α and β(1) subunits of the BK(Ca) channel, rather than...

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Detalhes bibliográficos
Main Authors: Maher, J, Hunter, A C, Mabley, J G, Lippiat, J, Allen, M C
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696336/
https://ncbi.nlm.nih.gov/pubmed/23586466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12211
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