Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes

BACKGROUND AND PURPOSE: The sphingosine 1-phosphate receptor subtype 1 (S1P1R) is modulated by phosphorylated FTY720 (pFTY720), which causes S1P1R internalization preventing lymphocyte migration thus limiting autoimmune response. Studies indicate that internalized S1P1Rs continue to signal, maintain...

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Hlavní autoři: Healy, Luke M, Sheridan, Graham K, Pritchard, Adam J, Rutkowska, Aleksandra, Mullershausen, Florian, Dev, Kumlesh K
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2013
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696333/
https://ncbi.nlm.nih.gov/pubmed/23587004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12207
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