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Non-parallel recombination limits Cre-LoxP-based reporters as precise indicators of conditional genetic manipulation
Cre/LoxP-mediated recombination allows for conditional gene activation or inactivation. When combined with an independent lineage-tracing reporter allele, this technique traces the lineage of presumptive genetically modified Cre-expressing cells. Several studies have suggested that floxed alleles ha...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3696028/ https://ncbi.nlm.nih.gov/pubmed/23441020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvg.22384 |
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