Progesterone receptor induces bcl-x expression through intragenic binding sites favoring RNA polymerase II elongation

Steroid receptors were classically described for regulating transcription by binding to target gene promoters. However, genome-wide studies reveal that steroid receptors-binding sites are mainly located at intragenic regions. To determine the role of these sites, we examined the effect of progestins...

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Hlavní autoři: Bertucci, Paola Y., Nacht, A. Silvina, Alló, Mariano, Rocha-Viegas, Luciana, Ballaré, Cecilia, Soronellas, Daniel, Castellano, Giancarlo, Zaurin, Roser, Kornblihtt, Alberto R., Beato, Miguel, Vicent, Guillermo P., Pecci, Adali
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Gene Regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695497/
https://ncbi.nlm.nih.gov/pubmed/23640331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt327
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