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APOBEC3G cytosine deamination hotspots are defined by both sequence context and single-stranded DNA secondary structure

Apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G (i.e., APOBEC3G or A3G) is an evolutionarily conserved cytosine deaminase that potently restricts human immunodeficiency virus type 1 (HIV-1), retrotransposons and other viruses. A3G has a nucleotide target site specificity for cyt...

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Detalhes bibliográficos
Main Authors: Holtz, Colleen M., Sadler, Holly A., Mansky, Louis M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695494/
https://ncbi.nlm.nih.gov/pubmed/23620282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt246
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