Bending of Adenovirus Origin DNA by Nuclear Factor I as Shown by Scanning Force Microscopy Is Required for Optimal DNA Replication

Nuclear factor I (NFI) is a transcription factor that binds to the adenovirus type 5 (Ad5) origin of replication and recruits the adenovirus DNA polymerase, thereby stimulating initiation of DNA replication in vitro. Using scanning force microscopy, we demonstrate that NFI induces a 60° bend upon bi...

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Detalhes bibliográficos
Main Authors: Mysiak, Monika E., Bleijenberg, Marjoleine H., Wyman, Claire, Holthuizen, P. Elly, van der Vliet, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC369512/
https://ncbi.nlm.nih.gov/pubmed/14747557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.4.1928-1935.2004
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