Mutant PrP(Sc) Conformers Induced by a Synthetic Peptide and Several Prion Strains

Gerstmann-Sträussler-Scheinker (GSS) disease is a dominantly inherited, human prion disease caused by a mutation in the prion protein (PrP) gene. One mutation causing GSS is P102L, denoted P101L in mouse PrP (MoPrP). In a line of transgenic mice denoted Tg2866, the P101L mutation in MoPrP produced n...

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Autori principali: Tremblay, Patrick, Ball, Haydn L., Kaneko, Kiyotoshi, Groth, Darlene, Hegde, Ramanujan S., Cohen, Fred E., DeArmond, Stephen J., Prusiner, Stanley B., Safar, Jiri G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
Soggetti:
Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC369494/
https://ncbi.nlm.nih.gov/pubmed/14747574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.4.2088-2099.2004
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