Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2)

We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production. Synthetic RNA silencing was target-specific and is a new tool for gene regulation and meta...

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Bibliographic Details
Main Authors: Uguru, Gabriel C., Mondhe, Madhav, Goh, Shan, Hesketh, Andrew, Bibb, Mervyn J., Good, Liam, Stach, James E. M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694883/
https://ncbi.nlm.nih.gov/pubmed/23826310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067509
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