Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2)

We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production. Synthetic RNA silencing was target-specific and is a new tool for gene regulation and meta...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Uguru, Gabriel C., Mondhe, Madhav, Goh, Shan, Hesketh, Andrew, Bibb, Mervyn J., Good, Liam, Stach, James E. M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2013
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694883/
https://ncbi.nlm.nih.gov/pubmed/23826310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067509
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