Budding Yeast ATM/ATR Control Meiotic Double-Strand Break (DSB) Levels by Down-Regulating Rec114, an Essential Component of the DSB-machinery

An essential feature of meiosis is Spo11 catalysis of programmed DNA double strand breaks (DSBs). Evidence suggests that the number of DSBs generated per meiosis is genetically determined and that this ability to maintain a pre-determined DSB level, or “DSB homeostasis”, might be a property of the m...

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Detalhes bibliográficos
Main Authors: Carballo, Jesús A., Panizza, Silvia, Serrentino, Maria Elisabetta, Johnson, Anthony L., Geymonat, Marco, Borde, Valérie, Klein, Franz, Cha, Rita S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694840/
https://ncbi.nlm.nih.gov/pubmed/23825959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003545
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