Chemoattractant stimulation of TORC2 is regulated by receptor/G protein–targeted inhibitory mechanisms that function upstream and independently of an essential GEF/Ras activation pathway in Dictyostelium

Global stimulation of Dictyostelium with different chemoattractants elicits multiple transient signaling responses, including synthesis of cAMP and cGMP, actin polymerization, activation of kinases ERK2, TORC2, and phosphatidylinositide 3-kinase, and Ras-GTP accumulation. Mechanisms that down-regula...

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Main Authors: Liao, Xin-Hua, Buggey, Jonathan, Lee, Yun Kyung, Kimmel, Alan R.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Cell Biology 2013
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694798/
https://ncbi.nlm.nih.gov/pubmed/23657816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-03-0130
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