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Role of Amphiphilicity in the Design of Synthetic Mimics of Antimicrobial Peptides with Gram-Negative Activity

[Image: see text] Two new series of aryl SMAMPs (synthetic mimics of antimicrobial peptides) with facially amphiphilic (FA) and disrupted amphiphilic (DA) topologies were designed and synthesized to directly assess the role of amphiphilicity on their antimicrobial activity against Gram-positive and...

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Main Authors: Thaker, Hitesh D., Cankaya, Alper, Scott, Richard W., Tew, Gregory N.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2013
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694626/
https://ncbi.nlm.nih.gov/pubmed/23814644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300307b
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