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Predominance of activated, clonally expanded T helper type 17 cells within the CD4(+) T cell population in psoriatic lesions

Recent evidence points to the T helper type 17 (Th17) subset as key in the pathogenesis of psoriasis, but cells of this type in lesions remain to be fully characterized. Here we isolated, enumerated, functionally tested and clonotyped the CD4(+) Th cell population ex vivo from lesional biopsies and...

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Detalhes bibliográficos
Main Authors: Lewis, B J, Rajpara, S, Haggart, A M, Wilson, H M, Barker, R N, Ormerod, A D
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694533/
https://ncbi.nlm.nih.gov/pubmed/23607572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12086
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