Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN

BACKGROUND: Inhibitor of differentiation 4 (Id4), a member of the helix-loop-helix family of transcriptional regulators has emerged as a tumor suppressor in prostate cancer. Id4 is expressed in the normal prostate where its expression is also regulated by androgens. In this study we investigated the...

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Bibliografske podrobnosti
Main Authors: Sharma, Pankaj, Knowell, Ashley Evans, Chinaranagari, Swathi, Komaragiri, Shravan, Nagappan, Peri, Patel, Divya, Havrda, Mathew C, Chaudhary, Jaideep
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694449/
https://ncbi.nlm.nih.gov/pubmed/23786676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-67
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