α-Synuclein mutations cluster around a putative protein loop()

With the recent identification of two new pathogenic mutations in α-synuclein, we map the five known pathogenic mutations onto the best available models of the protein structure. We show that four of the five mutations map to a potential fold in the protein with the exception being the A30P mutation...

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Bibliographic Details
Main Authors: Kara, Eleanna, Lewis, Patrick A., Ling, Helen, Proukakis, Christos, Houlden, Henry, Hardy, John
Format: Artigo
Language:Inglês
Published: Elsevier Scientific Publishers Ireland 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694303/
https://ncbi.nlm.nih.gov/pubmed/23669636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2013.04.058
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