A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer

BACKGROUND: Tumor cell fusion with motile bone marrow-derived cells (BMDCs) has long been posited as a mechanism for cancer metastasis. While there is much support for this from cell culture and animal studies, it has yet to be confirmed in human cancer, as tumor and marrow-derived cells from the sa...

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Autori principali: Lazova, Rossitza, LaBerge, Greggory S., Duvall, Eric, Spoelstra, Nicole, Klump, Vincent, Sznol, Mario, Cooper, Dennis, Spritz, Richard A., Chang, Joseph T., Pawelek, John M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694119/
https://ncbi.nlm.nih.gov/pubmed/23840523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066731
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