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Assessment of SLX4 Mutations in Hereditary Breast Cancers
BACKGROUND: SLX4 encodes a DNA repair protein that regulates three structure-specific endonucleases and is necessary for resistance to DNA crosslinking agents, topoisomerase I and poly (ADP-ribose) polymerase (PARP) inhibitors. Recent studies have reported mutations in SLX4 in a new subtype of Fanco...
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主要な著者: | , , , , , , , , , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
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Public Library of Science
2013
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オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3694110/ https://ncbi.nlm.nih.gov/pubmed/23840564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066961 |
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